Dr. Lauri Diehl
Genentech, South San Francisco, CA 94080, USA
Title: Dendritic cells in gut mucosal homeostasis
Biography
Biography: Dr. Lauri Diehl
Abstract
Dysfunction of the mucosal immune system leading to inappropriate recognition of commensal bacteria plays a central role in development of inflammatory bowel disease. Dendritic cells (DCs) are emerging as critical mediators of immune homeostasis through selective induction of immune responses. DCs form an extensive network in the intestinal lamina propria, project transepithelial dendrities to sample the luminal environment, and deliver antigens to mesenteric lymph nodes to induce either tolerance or immune response. While DCs are recognized as critical in maintaining mucosal homeostasis, the mechanisms by which they fulfill this role have not been fully elucidated. The role of CD83 homotypic interactions in DC regulation and other emerging mechanisms will be reviewed.
