Jessy Deshane
Division of Pulmonary Allergy and Critical Care Medicine, University of Alabama at Birmingham, USA
Title: Myeloid-Derived Regulatory Cells and Immune regulation in Asthma
Biography
Biography: Jessy Deshane
Abstract
This lecture will address the expanding role for macrophages and their plasticity highlighting their potent inflammatory and immunoregulatory activities in chronic lung diseases, specifically asthma. The intriguing role played by environmental exposures that regulate their plasticity, both in differentiation and function of these immature myeloid cells will be discussed. Important insights will be shared regarding how proportions and functions of subsets of regulatory myeloid cells can discriminate asthma from chronic obstructive pulmonary disease. In addition, this lecture will discuss new paradigms on pathogenesis of asthma based on a major role for myeloid-derived regulatory cells as regulators of balance between immune tolerance and inflammation by eliciting a pathologic immune/inflammatory response that represents a novel form of autoimmunity.
