Walter Schubert
ToposNomos Ltd., Germany
Title: The human toponome project: Translating the spatial protein network code into efficient therapies
Biography
Biography: Walter Schubert
Abstract
Imaging cycler® technology (IC®M) is presented as key thenology for (i) the spatial resolution of large protein networks at the target sites of disese with a discriminatory power for an unlimited number or proteins at a time (dimension unlimited imaging); (ii) for the in situ detection of thousands of distinct multi protein complexes; (iii) for the construction of machines able to decode the mechanism of cell invasion into organs, such as the invasion of autoimmune cells and cancer cells, and (iv) application of this technology for the efficient finding of therapies selectively blocking these invasions. The example of amyotrophic lateral sclerosis (ALS) is presented showing that (i) “ALS cells” were seen by IC® for the first time in the blood, (ii) the mechanism of CNS invasion and pathogenic neuronal axotomy of these cells was completely decoded by IC®, and (iv) these “ALS cells” were efficiently depleted in blood of patients. This ALS example can be translated for other diseases based on cell invasion. The IC® detection of somatotopic coding in the innate immune system is key.
