Inflammation

Inflammation is a fundamental biological response triggered by harmful stimuli such as pathogens, damaged cells, or irradiation. It represents a protective mechanism aimed at eliminating the source of injury and initiating tissue repair. The classic signs of acute inflammation include pain (dolor), heat (calor), redness (rubor), swelling (tumor), and loss of function.

As a key component of innate immunity, inflammation is a nonspecific response that acts rapidly to control threats, in contrast to adaptive immunity, which provides a pathogen-specific, delayed response. To prevent immunopathology damage caused by excessive immune activation the inflammatory process is tightly regulated by various endogenous molecules that control the magnitude and duration of the response.

An inadequate inflammatory response can result in uncontrolled tissue damage and failure to eliminate harmful agents, potentially threatening the organism’s survival. On the other hand, chronic or dysregulated inflammation can contribute to the development of numerous diseases, including hay fever, periodontitis, atherosclerosis, rheumatoid arthritis, and even certain cancers, as studied in cancer immunology.

Thus, precise regulation of inflammation is essential to balance host defense with the preservation of tissue integrity and overall health.

 

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