Innateimmunity

Therapeutic applications

The innate immune system plays a critical role both systemically and locally in the development and regulation of infectious and inflammatory diseases. A deeper understanding of its underlying mechanisms has been pivotal in the development of vaccines, vaccine adjuvants, and anti-inflammatory therapeutics.

Key components of innate immunity, such as pattern-recognition receptors (PRRs) including Toll-like receptors (TLRs), retinoic acid-inducible gene I (RIG-I)-like helicases, and nucleotide-binding oligomerization domain (NOD)-like receptors have emerged as promising therapeutic targets, given their central role in the pathogenesis of numerous diseases.

Additionally, proteolytic systems such as autophagy and immunoproteasomes are essential for innate immune function and present further potential for drug development. Leveraging these innate mechanisms, researchers have made significant progress in creating innovative preventive and therapeutic strategies.

Our recent studies have contributed to this evolving field by developing novel vaccines and adjuvants based on mechanistic insights into innate immune signaling. We have also investigated the interactions between the innate immune system and the endocrine system, revealing new perspectives on how innate immunity influences metabolic and endocrine disorders.

This review highlights the potential of innate immune molecules as immunomodulatory agents and explores their future applications in treating a wide range of inflammatory and metabolic diseases, marking a significant advancement in translational immunology.