Neural regulation
The central nervous system (CNS) plays a critical role in regulating innate immune responses through both hormonal and neuronal pathways. The neuroendocrine stress response, along with the sympathetic and parasympathetic branches of the autonomic nervous system, generally acts to suppress innate immune activity at both systemic and regional levels. In contrast, the peripheral nervous system often functions to enhance local immune responses, particularly at sites of infection or injury.
These systems interact dynamically to ensure a balanced immune response. Initially, they work in concert to activate and amplify local inflammatory reactions, helping to contain or eliminate invading pathogens. Once the threat is resolved, these same pathways contribute to terminating inflammation and restoring homeostasis within the host.
Emerging evidence suggests that the CNS is not merely a passive observer but an active participant in the regulation of acute-phase immune responses. Given its influence on immune activation, suppression, and resolution, the CNS can be regarded as an integral component of the body’s response to infection, functioning in close coordination with the innate immune system.
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